Thioredoxin has also been shown to bind to ASK1 to inhibit its activity like a kinase [32]. This inhibition is attenuated by ROS that can cause dimerization of thioredoxin [33]. Thioredoxin regulation with the glucocorticoid receptor through association at the DNA binding domain has also been documented [34] and this way too is affected by ROS. Ext… Read More

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